Investigation of the Anti-HIV Properties of Oxihumate
in-vitro Grade C 2002
Authors: van Rensburg, C.E.J., Dekker, J., Weis, R., Smith, T.-L., Janse van Rensburg, E., Schneider, J.
Journal: Chemotherapy 48 (3) : 138-143
DOI: 10.1159/000064919
Key Findings
- Oxihumate — a water-soluble humate produced from bituminous coal, not peat — inhibited HIV-1 infection of MT-2 cells with an IC50 of 12.5 µg/ml
- The effect acted on the virus itself: pre-treating target cells conferred no protection, but treating free or cell-attached virus irreversibly reduced infectivity
- Proposed mechanism: interference with CD4 binding and V3-loop-mediated viral entry
- No viral resistance developed over 12 weeks of in vitro passage
An in-vitro study of oxihumate, a coal-derived (not peat-derived) humic substance, showing potent and durable inhibition of HIV-1 infectivity through interference with viral entry, with no resistance emerging over 12 weeks. This is the strongest antiviral potency data for any humic-substance-class material in this library, but it is not peat-derived — oxihumate here is manufactured from bituminous coal — so it is treated as corroborating evidence for the humic-substance mechanism class generally, not as peat-specific proof. Abstract-only sourcing; no full text was located.
humic-substanceantiviralin-vitrocoal-derivednot-peat-specific